Crystallization of water into ice is lethal to most organisms and detrimental to many soft materials. Freeze-avoidant fish living in polar seas evolved to tackle this problem with an unusual coping strategy. They produce ‘antifreeze’ proteins that block the growth of embryonic ice crystals within a narrow temperature range known as the ‘thermal hysteresis gap’ enabling survival under extreme conditions. In this project you will study recently developed biosynthetic protein-polymers which inhibit ice recrystallization and engineer optimized materials based on your findings. You will work in close collaboration with other group members who study bioinspired macromolecular antifreezes and use super-resolution imaging to measure ice-binding at the single molecule level. Our aim is to unravel how ice-binding proteins work and to better understand the functionality of biomimetic and biosynthetic antifreezes to custom-tailor these for biomedical applications.
We seek highly talented, self-motivated, and enthusiastic candidates with a PhD degree in Biological Soft Matter, Protein Biophysics, Biophysical Chemistry, or Molecular Life Sciences. The successful candidate has experience with quantitative microscopy, (computer-aided) protein engineering, and protein biophysics; knowledge of crystallization and microfluidics is preferred. Furthermore, good communication skills, fluency in English, and a strong motivation to do original, fundamental research in an interdisciplinary team are essential. An interview and a scientific presentation are part of the selection process.
The candidate is expected to disseminate the results through high-impact publications in peer-reviewed journals and presentations at international conferences.
Do you recognize yourself in this profile and would you like to know more?
Please contact Prof. Ilja Voets, i.voets[at]tue.nl or +31 40 247 5303.
For information about terms of employment, please contact Leo van Houten,
HR-Advisor, l.v.houten[at]tue.nl or +31 40 247 8269.
Please visit www.tue.nl/jobs to find out more about working at TU/e!
We invite you to submit a complete application by using the 'Solliciteer nu'-button on this page. To ensure consideration, your application should include the following documents (in PDF format):
We look forward to your application and will screen it as soon as we have received it. Screening will continue until the position has been filled.