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PhD student Digital Twinning for a Serious and Personalized Diabetes Game (V50.4255)

PhD student Digital Twinning for a Serious and Personalized Diabetes Game

Eindhoven University of Technology (TU/e) has the following vacancy for a PhD student Digital Twinning for a Serious and Personalized Diabetes Game (V50.xxxx) in the research group of Prof. Natal van Riel in the Computational Biology group at the Department of Biomedical Engineering.
Faculteit Biomedische Technologie


The PhD candidate will develop and apply dynamic models of human metabolic physiology to develop ‘Digital Twins’ of patients with diabetes. Digital twins are virtual copies of human metabolic physiology that enable simulations based on data collected from the patient and artificial intelligence. The models are expected to perform realistic simulation of glucose and insulin dynamics in response to the intake of food, the effect of medication, physical activity and mental stress and should allow for large differences between individuals.

The PhD position is part of the NWO funded project 'DiaGame: serious and personalized game for self-management of diabetes.' The DiaGame project applies learning systems and biomedical simulations to develop a data-driven, personalized serious game that empowers individuals with diabetes to manage the disease they are facing. In order to personalize the game, we will integrate our expertise on processing of personal data collected from health-related smartphone apps into our game platform. The information that this approach yields will be used to personalize the simulation that drives the game. Together, this will allow the use of patient-gathered health data to make the diabetes game a realistic representation of the condition of the gamer. Hence, the goal is to obtain a personalized simulator for a person's metabolism. In this way, DiaGame will change the approach to diabetes care by using data sciences in support of a data-driven personal diabetes games for learning to manage their own disease. Ultimately, this will improve the quality of life for patients and lighten the socio-economic and medical burden that diabetes has. The partners in the project include the Department of Industrial Engineering & Innovation Sciences of TU/e and Maxima Medical Centre in Eindhoven.

Tasks and responsibilities

The PhD candidate is expected to:

  • Perform research in an interdisciplinary team of international scientists.
  • Develop dynamic models of human metabolic physiology.
  • Apply these models to quantitative measurements from individuals with diabetes, including data from wearables and health apps.
  • Produce software tools to enable use in the wider scientific community.
  • Publish findings in peer-reviewed journals and present at international scientific conferences.
  • Write a PhD thesis.


We are looking for high-level candidates with an MSc degree in engineering and life sciences (biomedical engineering, biotechnology, bioengineering) with specialization in computational modelling, computational biology, or equivalent. She or he should be interested in quantitative methods, modelling and data integration with affinity for human metabolism and its regulation.

The candidates should have:

  • An MSc degree in engineering and life sciences, such as biomedical engineering, biotechnology, bioengineering, or equivalent.
  • A strong education track-record that includes topics such as dynamic modelling, systems biology, computational biology, data science, or equivalent.
  • Strong demonstrable analytical skills.
  • A proven ability to write computer code and to organise data.
  • Strong communication skills, including excellent proficiency in English (spoken and written).
  • Affinity for working in an interdisciplinary and highly international environment.
  • Good organisational skills.


We offer:

  • A challenging job at a dynamic and ambitious university.
  • Support to your personal development and career planning.
  • A full-time employment for 4 years. Gross monthly salaries are in accordance with the Collective Labour Agreement of the Dutch Universities (CAO NU), increasing from € 2325 per month initially, to € 2972in the fourth year.
  • An attractive package of fringe benefits (including excellent work facilities, end of the year allowance, and sport facilities).

Informatie en sollicitatie

More information can be obtained from:


Please upload your application with extended curriculum vitae.