This vacancy is posted as part of an ERC Advanced Award, Adolescent Idiopathic Scoliosis (AIS): a Perfect Storm of Functional Anatomy, Biomechanics and Mechanobiology during Growth? (ScoliStorm). AIS is a 3D deformity of the spine affecting previously healthy children, substantially reducing their quality of life and creating a life-long burden of disease. Till now, no curative treatment exists partly because its cause and disease mechanism are still unknown. ScoliStorm will create a paradigm shift in AIS research by uncovering its complex perfect storm of anatomical, biomechanical and mechanobiological causes in the intervertebral disc.
Currently we do not understand how human disc tissue properties change during adolescent growth. Combining this first-time knowledge with that of disc loading during growth, we aim to explore the conditions that could lead to disc and spinal deformation. We strive to use biochemical analysis, multiplex in situ hybridization, immuno-histochemistry, differential interference contrast and second harmonic generation microscopy, quantitative digital image analysis, HR-pQCT, ultrahigh-field MRI and mechanical testing on cadaveric human spinal motion segments. You will contribute to a multi-disciplinary team of biomedical engineers, imaging scientists and spine surgeons, from the student to senior level, working on engineering, biological, imaging and clinical studies. Together we will strive to elucidate the causes for AIS and identify predictive triggers to prevent and treat scoliosis in these unfortunate children.
About Eindhoven University of Technology (TU/e)
TU/e is a University of Technology with a focus on Health, Energy and Mobility. Within the Health area, several departments cooperate on topics such as Chemical Biology, Regenerative Medicine, Computational Biology, and Biosensing, with close links to healthcare and industry. TU/e is an open and inclusive university with short communication lines. The people are curious, collaborative, and strive for excellence. TU/e enables its academic staff to develop research and education at an internationally renowned level. Our lively campus community facilitates connections between staff and students, in an open, friendly, vibrant atmosphere that welcomes and inspires.
The Department of Biomedical Engineering (BME) offers a research driven BME Bachelor program and Masters in Biomedical Engineering and Medical Engineering in its Graduate Program. Its research areas range from Molecular Bioengineering and Imaging, Biomechanics and Tissue Engineering to Biomedical Imaging and Modelling. The department has more than 800 students and up to 200 tenured and non-tenured employees.
The research will be mainly conducted within the Orthopaedic Biomechanics (OPB) group in the Department of Biomedical Engineering.
The OPB group, headed by prof.dr. K. Ito, combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. They cover diverse topics in bone, intervertebral disc and tendons/ligaments, as well as articular cartilage. The group is well known for their multidisciplinary approach combining tissue mechanics, mechanobiology, tissue and biomaterial mechanics, ex vivo bioreactor platforms and computational models to optimize tissue conditions for regenerative engineering. The group houses the Cell and Tissue Engineering laboratory, a shared research infrastructure operating at the international forefront of the engineering of living, load-bearing tissues.
Do you recognize yourself in this profile and would you like to know more? Please contact
prof. Keita Ito (k.ito[at]tue.nl).
For information about terms of employment, click here or contact Sascha Sanchez, HR advisor, s.j.m.g.sanchez.van.oort[at]tue.nl or HRServices.Gemini[at]tue.nl.
Please visit www.tue.nl/jobs to find out more about working at TU/e!
We invite you to submit a complete application by using the 'apply now'-button on this page.
The application should include a:
We look forward to your application and will screen it as soon as we have received it. Screening will continue until the position has been filled.
We do not respond to applications that are sent to us in a different way.
Please keep in mind you can upload only 5 documents up to 2 MB each. If necessary, please combine files.