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High-throughput microfluidic platform for studying cell-material interactions

High-throughput microfluidic platform for studying cell-material interactions

PhD position in high-throughput microfluidic platform for studying cell-material interactions.
Aanstellingsfunctie(s)
Promovendus
Faculteit(en)
Faculteit Biomedische Technologie
FTE
1,0
Sluitdatum
31/08/2020
Aanvraagnummer
V50.4480

Functieomschrijving

Eindhoven University of Technology (TU/e) is seeking a bright Ph.D. candidate to develop Lab-on-a-Chip devices for high-throughput cell culturing and analysis for the investigation of crosstalk between cells and biomaterials, which are used in regenerative medicine. The device functions as the initial stage of a very powerful cell-screening microarray.

The successful candidate should be excited about both biomaterials engineering, cell biology, and microfabrication. Doctoral research will be part of wider and exciting efforts currently spearheaded within the BioInterface Science Research Group.

Crosstalk between cells and (bio)materials plays a key role in the cell differentiation process in regenerative medicine applications. For these applications, engineered biomaterials embedded in microfluidic platforms can create functional and impactful research tools for cell-screening. In this project, you will develop innovative approaches to investigate cell-material interactions and subsequent cell response.

You will contribute to the high-throughput cell screening program of the Biointerface Science Research Group. The core of the Lan-on-a-Chip device will be several hundreds of independent cell-culturing microunits with fluidic access to culture media with different compositions. In this array, separate units will exploit the multiplexed analysis of biomolecules in real-time. You will design and manufacture the devices. Furthermore, you will design and build a measurement setup, where you will perform and interpret the measurements. Proteins, nucleic acids, and cell secretome are targeted analytes. It will be important to develop a good data analysis insight into the different factors (that alter the cell behavior), which if necessary, can be modeled using an analytical or finite-element based approach. You are expected to do scientific research in the field described above, write a doctoral thesis, and publish research results in scientific journals. An educational and professional development program is offered to all Ph.D. candidates by TU/e. 

Functie-eisen

We are accepting applications from enthusiastic and highly talented candidates who are interested in a dynamic, stimulating, and ambitious environment to perform their research. We are looking for candidates that meet the following requirements:

  • A master’s degree (or an equivalent university degree) in Bioengineering, Biotechnology, Materials Engineering, Mechanical Engineering, Microfabrication. 
  • Prior experience with microscopy techniques and cell culture/co-culture is a plus along with competencies in computer-based quantification/analysis tools
    (Matlab or similar).
  • A research oriented attitude.
  • Ability to independently work within a dynamic team and to foster collaborations.
  • Fluent in spoken and written English.

The position will be based at the Eindhoven University of Technology (TU/e) in the Netherlands. Doctoral research will be performed within the BioInterface Science (BiS) group in the Department of Biomedical Engineering under the supervision of dr. Burcu Gumuscu-Sefunc and prof. Jan de Boer. Research at BiS is dedicated to understanding and applying basic cell biological principles at the biointerfaces, especially for regenerative medicine.

The research program is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling, and experimental biology to streamline the wealth of biological knowledge to real clinical applications.

Arbeidsvoorwaarden

  • A meaningful job in a dynamic and ambitious university with the possibility to present your work at international conferences.
  • A full-time employment for four years, with an intermediate evaluation after one year.
  • To support you during your PhD and to prepare you for the rest of your career, you will have free access to a personal development program for PhD students (PROOF program).
  • A gross monthly salary and benefits in accordance with the Collective Labor Agreement for Dutch Universities.
  • Additionally, an annual holiday allowance of 8% of the yearly salary, plus a year-end allowance of 8.3% of the annual salary.
  • A broad package of fringe benefits, including an excellent technical infrastructure, moving expenses, and savings schemes.
  • Family-friendly initiatives are in place, such as an international spouse program, and excellent on-campus children day care and sports facilities.

Informatie en sollicitatie

More information

Do you recognize yourself in this profile and would you like to know more?
Please contact dr. Gumuscu-Sefunc, Assistant Professor, b.gumuscu[at]tue.nl or
+31 40 247 8373.

Additional information on the department you can find on:

For information about terms of employment, please contact Sascha Sanchez,
HR advisor, s.j.m.g.sanchez.van.oort[at]tue.nl or +31 40 247 7310.

Please visit www.tue.nl/jobs to find out more about working at TU/e!

Application

We invite you to submit a complete application by using the 'solliciteer nu'-button on this page. The application should include a:

  • Cover letter in which you describe your motivation and qualifications for the position.
  • Curriculum vitae, including a list of your publications and the contact information of three references.
  • Academic transcripts
  • Brief description of your MSc thesis.

We look forward to your application and will screen it as soon as we have received it. Screening will continue until the position has been filled.