PhD position ‘Artificial organelles based on polymersome nanoreactors’ (m/v) (V37.2868)
PhD position ‘Artificial organelles based on polymersome nanoreactors’ (m/v)
Our ambition is to create hybrid cells and organelles that can be used to mimic and adjust cellular processes. We employ expertise from polymer science, nanotechnology and cell biology to achieve our goals. Are you the enthusiastic PhD student that fits in our group of excellent researchers?
The research of the group Bio-organic Chemistry focuses on compartmentalization strategies to construct micro and nanocapsules which can be applied in the areas of nanomedicine and artificial cell research. We design smart delivery vehicles that for example cross the blood brain barrier or are used in cancer therapy. We use nanoparticles as scaffolds for vaccine development. We construct capsules with life-like properties, such as metabolism, organelle-mimetic behavior and cell growth and motility. In our research we combine techniques from protein engineering, polymer chemistry and bioconjugation approaches to create particles with bioactive properties.
A PhD position is open in the field of artificial organelles:
Biodegradable polymer nanoreactors that operate in the cytoplasm of mammalian cells
The aim of this project is to introduce artificial organelles in living cells with high level of control, to design hybrid cells with acquired functionality. This investigation is of great interest from a fundamental scientific point of view, as it will shed light on the tolerance of cells to accommodate novel structures. Furthermore, this investigation also serves an important societal goal, as with these novel compartments dysfunctional cellular processes can potentially be corrected.
First, you will design, synthesize and characterize a series of biodegradable block copolymers which have the ability to self-assemble into well-defined polymer vesicles. Secondly, the membrane will be made semi-permeable for small molecules, whereas enzymes remain entrapped inside the vesicle. The third objective is to design smart methods for introducing the nanoreactors in the cytoplasm of living mammalian cells. Finally, the acquired enzymatic activity of the cells will be investigated and applied in diseased cell models to counteract dysfunctional enzymes.
We are looking for a talented and enthusiastic (almost) graduated Master student in Chemistry, preferably with a background in polymer chemistry and nanoscience, and with an affinity for cell biology. Other requirements are excellent analytic and communicative skills. You are fluent in English and you like to work in a multidisciplinary team.
Conditions of employment
We offer a challenging job for four years in a highly motivated team at a dynamic and ambitious University. You will work with innovative analytic equipment and you will be part of a highly profiled multidisciplinary collaboration where expertise of a variety of disciplines comes together. The TU/e is located in one of the smartest regions of the world en part of the European technology hotspot ‘Brainport Eindhoven’; well-known because of many high-tech industries and start-ups. A place to be for talented scientists! The gross monthly salary in accordance with the Collective Labor Agreement of the Dutch Universities (CAO NU), starts with € 2.191,= in the first year to € 2.801,= in the fourth year. Besides this the TU/e has holiday- and end-of the year allowances, an excellent package of attractive benefits for employees and a modern sports complex. Assistance for finding accommodation can be given. Especially for PhD students the TU/e also offers opportunities for personal development. We do this by offering every PhD student a series of courses that are part of the Proof program as an excellent addition to your scientific education.
Information and application
More information about this vacancy can be obtained with prof. dr. ir. Jan van Hest (e-mail: firstname.lastname@example.org;
More information about job conditions and application can be obtained with mrs. Linda van den Boomen (email: email@example.com)
The application should consist of the following parts:
- a brief letter explaining/motivating your interest in the position;
- a detailed Curriculum Vitae, including a list of publications (if appropriate);
- a complete list of courses taken and grades obtained (including transcripts of academic records);
- one-page summary of the MSc thesis;
- contact details of two referees;
- proof of English language skills (if applicable);
- any other relevant information.
Please send us your application before May 3rd 2017. using the 'apply now'-button on top of this page.